Crush...Yiff...Destroy! Crush...Yiff...Destroy!
The CYD Forum Archive
 

Scientists Decipher DNA of Dogs/Humans
   Crush...Yiff...Destroy! Forum Archive Index -> News
Author Message
EFudd
Prattler
Joined: 12 May 2005
Posts: 139

Posted: 12/8/2005 10:50:09 AM     Post subject: Scientists Decipher DNA of Dogs/Humans  



From the smallest Chihuahua to the biggest Great Dane, all dogs emerge from the same basic set of genes. Scientists announced Wednesday that they'd deciphered this doggie DNA and begun detailed comparisons between breeds and with humans.

The work should help researchers find genes that make dogs and people vulnerable to such illnesses as cancers, heart disease, cataracts, epilepsy, blindness and deafness. And it has already hinted that people may have fewer genes than scientists thought.

The work used the DNA of a female boxer named Tasha, said Eric Lander, director of the Broad Institute of Harvard and MIT and senior author of the analysis in Thursday's issue of the journal Nature. The DNA project was led by Kerstin Lindblad-Toh of the institute.

Tasha was chosen from more than 100 candidate dogs because her DNA looked especially amenable to the task of identifying its 2.4 billion chemical building blocks. But it turned out that any other dog would have worked just as well, Lander said.

The results are more complete than those announced in 2003 for the DNA of a male poodle named Shadow.

Scientists have also deciphered the DNA of mice, rats, chimps, chickens and of course humans, as well as many other organisms.

At the DNA level, two randomly chosen dogs differ by only about as much as two randomly chosen people do, yet the variation in appearance, size and behavior in dogs is "just mind-boggling," Lander said.

"How is it within one narrow gene pool you can produce Chihuahuas and Great Danes?" he asked.

Much of the answer involves differences in turning gene activity on and off, he said, and further study could help scientists understand what produces big differences in body plans between species.

The new work also identified signposts along the canine DNA that will help in finding genes that predispose dogs to certain diseases, some of which they share with humans. The dog genes should point the way to their human counterparts, Lander said.

In fact, it may be vastly easier to find disease genes in dogs than in people. Intensive breeding has left its mark in the dog genome so that finding DNA regions that contain disease genes "is like hitting the side of a barn," Lander said.

Such genetic research should benefit dogs and their owners, said William Truesdale, a board member of the American Kennel Club's Canine Health Foundation, which had put $2 million into the dog DNA project.

"We're trying to erase these genetic frailties" by screening dogs for disease genes prior to breeding, he said.

That effort is now in its infancy, but as more of those genes are uncovered they can be eliminated by breeding dogs that don't carry them, he said. And puppies can be tested to assure their owners that they won't get the associated diseases later, "like a Good Housekeeping seal," Truesdale said.

Dog DNA is already teaching several lessons about human DNA. For one thing, comparisons between DNA of dogs, humans and mice revealed elaborate controls on the activity of certain human genes active in early development, Lander said.

The three-way comparisons also showed that some genetic features found in humans but not mice aren't really unique to people, but also appear in dogs, he said. "The more species we look at, the more, frankly, we find that humans are not exceptional here," Lander said.

Researchers also estimated that dogs have 19,300 genes, almost all of them canine versions of genes found in people. Prior studies have indicated that people have about 3,000 more, but Lander said the dog analysis "is leading us to question whether those are in fact real human genes." Some proposed human genes, he said, are now "suspect" and may not be genes at all.

___

So in thoery, by turning on or off the gene similarities between a white tiger and a skunk in the breeding process... Hmm.
Back to top
View user's profile Send private message
The Flying Fox
Coadjutor
Joined: 05 Sep 2005
Posts: 93

Posted: 12/8/2005 4:49:29 PM     Post subject:  

I can already see Eric Schwartz running to the labs.
Back to top
View user's profile Send private message
MonicaKitty
Vociferator
Joined: 24 Feb 2005
Posts: 663

Posted: 12/8/2005 8:41:28 PM     Post subject:  

You know, even if they somehow managed to pull off some kind of animal-human hybrid, it wouldn't be the Schwartzian ideal of beautiful, busty fox/skunk/whatever women. They'd look more like this
Back to top
View user's profile Send private message
Duck Stab
Qualificator
Joined: 15 Oct 2004
Posts: 36

Posted: 12/8/2005 9:12:58 PM     Post subject:  

there are some seriously pseudoscientific consensus ideas on genetics in the press lately, the biggest of which is assuming that chromosomes act like a blueprint.
Back to top
View user's profile Send private message
Philip Savage
Prattler
Joined: 17 Nov 2005
Posts: 129

Posted: 12/8/2005 11:22:34 PM     Post subject:  

Uh-oh. Friendly neighborhood dogfuckers may mistake this for justification of their very...special...fetishes.

They'd look more like this

:shock: ...I want an army of them...
Back to top
View user's profile Send private message
peppersprayed
Vociferator
Joined: 23 Aug 2005
Posts: 369

Posted: 12/8/2005 11:29:30 PM     Post subject:  

Uh-oh. Friendly neighborhood dogfuckers may mistake this for justification of their very...special...fetishes.

They'd look more like this

:shock: ...I want an army of them...


You've never seen the fly have you?
Back to top
View user's profile Send private message
Donotsue
Needs to get out more
Joined: 17 Jan 2004
Posts: 884

Posted: 12/9/2005 12:26:44 AM     Post subject:  

Back to top
View user's profile Send private message
Philip Savage
Prattler
Joined: 17 Nov 2005
Posts: 129

Posted: 12/9/2005 1:33:27 AM     Post subject:  

You've never seen the fly have you?

...nope...
Back to top
View user's profile Send private message
peppersprayed
Vociferator
Joined: 23 Aug 2005
Posts: 369

Posted: 12/9/2005 1:35:38 AM     Post subject:  

You've never seen the fly have you?

...nope...


dude builds a teleportation device and a fly enters the chamber

he comes out normal at first.... but slowly turns into, well that thing
Back to top
View user's profile Send private message
AngryPuritan
Needs to get out more
Joined: 15 Jan 2005
Posts: 1361

Posted: 12/9/2005 1:44:25 AM     Post subject:  

You've never seen the fly have you?

...nope...


dude builds a teleportation device and a fly enters the chamber

he comes out normal at first.... but slowly turns into, well that thing


The original was so less pretentious...
Back to top
View user's profile Send private message
MonicaKitty
Vociferator
Joined: 24 Feb 2005
Posts: 663

Posted: 12/9/2005 1:45:56 AM     Post subject:  



The original was so less pretentious...


Yes, but the original didn't have corrosive vomit. =)
Back to top
View user's profile Send private message
peppersprayed
Vociferator
Joined: 23 Aug 2005
Posts: 369

Posted: 12/9/2005 1:47:35 AM     Post subject:  

You've never seen the fly have you?

...nope...


dude builds a teleportation device and a fly enters the chamber

he comes out normal at first.... but slowly turns into, well that thing


The original was so less pretentious...


hmm I thought the plot was more or less the same in both the original and remake?
Back to top
View user's profile Send private message
AngryPuritan
Needs to get out more
Joined: 15 Jan 2005
Posts: 1361

Posted: 12/9/2005 2:22:27 AM     Post subject:  

Nope. In the original, the scientist had a wife, and it starts off with her talking to the police about having murdered him. The fly and scientist don't merge, but rather 'switch parts'. So... well, I don't want to spoil it all, but the original has equal parts hookeyness and a more subtle questioning of what is human.
Back to top
View user's profile Send private message
Evil
Rasophore
Joined: 24 Sep 2005
Posts: 62

Posted: 12/9/2005 2:29:59 AM     Post subject:  

more like this


Fifteen minutes before the first porn would appear on fchan.
Back to top
View user's profile Send private message
Captain Cowgirl
Needs to get out more
Joined: 27 May 2005
Posts: 1091

Posted: 12/9/2005 3:19:56 AM     Post subject:  


OH GOD DONNY I LOVE YOU
Back to top
View user's profile Send private message
MonicaKitty
Vociferator
Joined: 24 Feb 2005
Posts: 663

Posted: 12/10/2005 9:54:22 PM     Post subject:  

more like this


Fifteen minutes before the first porn would appear on fchan.


Pffft, too late already. Lest we forget Maggot Girl.



I'd say it's an improvment. He's lost like 900 lbs and I'll bet vomiting on his food to dissolve it is less offensive than his current eating habits.
Back to top
View user's profile Send private message